International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 177)
CAS No.: 238-84-6
Chem. Abstr. Name: 11H-Benzo(a)fluorene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Benzo[a]fluorene was tested for carcinogenicity in mice in one
study by skin application and in a mouse-skin initiation-promotion
assay. Negative results were obtained in both studies. In a study
involving subcutaneous administration of benzo[a]fluorene to mice, no
injection-site tumour was observed.
No data on the teratogenicity of this chemical were available.
The available data were inadequate to evaluate the mutagenicity
of benzo[a]fluorene to Salmonella typhimurium.
There is inadequate evidence that benzo[a]fluorene is active in
5.2 Human data
Benzo[a]fluorene is present as a minor component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to benzo[a]fluorene occurs primarily through the smoking of
tobacco, inhalation of polluted air and by ingestion of food and water
contaminated with combustion products.
The available data were inadequate to permit an evaluation of the
carcinogenicity of benzo[a]fluorene to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)
Last updated: 17 April 1998