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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NITHIAZIDE

VOL.: 31 (1983) (p. 179)

CAS No.: 139-94-6
Chem. Abstr. Name: Urea, N-ethyl-N'-(5-nitro-2-thiazolyl)-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Nithiazide was tested for carcinogenicity in one experiment in mice and in one experiment in rats by administration in the diet. It increased the incidence of hepatocellular carcinomas and adenomas in male mice. In female rats, it increased the incidences of fibroadenomas and cystadenomas of the skin, subcutaneous tissue and mammary gland (significant only if individual incidences for each site were combined) and the incidence of endometrial stromal polyps of the uterus.

No data were available to assess the mutagenic or teratogenic effects of nithiazide in experimental systems.

5.2 Human data

Nithiazide, a synthetic antiprotozoal agent, was first produced in 1961. Humans may be exposed as a result of its manufacture and use in veterinary medicine.

No data were available to assess the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of nithiazide was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of nithiazide in experimental animals. In the absence of epidemiological data no evaluation of the carcinogenicity of nithiazide to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)

Synonyms


Last updated: 16 April 1998






















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