International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 191)
CAS No.: 117-79-3
Chem. Abstr. Name: 9,10-Anthracenedione, 2-amino-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
2-Aminoanthraquinone (technical grade of low purity) was tested in one
experiment in mice and in one experiment in rats by dietary
administration. It produced hepatocellular carcinomas in mice of both
sexes and in male rats.
Purified 2-aminoanthraquinone was not mutagenic to Salmonella
5.2 Human data
2-Aminoanthraquinone has been produced commercially since at least
1921. Its use as an intermediate in the manufacture of dyes and
pigments could result in occupational exposure.
No case report or epidemiological study was available to the Working
There is limited evidence for the carcinogenicity in experimental
animals of the material tested, which was technical-grade
2-aminoanthraquinone of low purity.
In view of the uncertain purity of the compound tested and in the
absence of data on humans, no evaluation of the carcinogenicity of
2-aminoanthraquinone could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 3)
Last updated: 8 April 1998