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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIHYDROXYMETHYLFURATRIZINE

VOL.: 24 (1980) (p. 77)

CAS No.: 794-93-4
Chem. Abstr. Name: Methanol, {([6-[2-(5-nitro-2-furanyl)ethenyl]-1,2,4-triazin-3-yl]imino}bis-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dihydroxymethylfuratrizine was tested alone in female rats by oral administration. Although a few tumours of the small intestine were observed in treated animals, there was no difference in overall tumour incidence as compared with controls. Panfuran-S, a commercial formulation which contains dihydroxymethylfuratrizine, was also tested in male mice and male rats by oral administration; it induced benign and malignant tumours of the forestomach and small intestine in animals of both species and of the oesophagus in mice.

Attention is drawn to the absence of studies on the teratogenicity of this compound.

5.2 Human data

Dihydroxymethylfuratrizine in the form of Panfuran-S has been used in the past for treatment of acute gastrointestinal infections.

No case reports or epidemiological studies were available to the Working Group.

5.3 Evaluation

There are insufficient data to evaluate the carcinogenicity of dihydroxymethylfuratrizine alone in experimental animals. There is sufficient evidence that Panfuran-S, a commercial formulation which contains dihydroxymethylfuratrizine and several other compounds, is carcinogenic in experimental animals.

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Dihydroxymethylfuratrizine - Group 3) (p. 69: Panfuran-S (containing dihydroxymethylfuratrizine) - Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms for Dihydroxymethylfuratrizine


Last updated: 7 April 1998






















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