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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

para-DIMETHYLAMINOAZOBENZENE

VOL.: 8 (1975) (p. 125)

CAS No.: 60-11-7
Chem. Abstr. Name: N, N-Dimethy1-4-(phenylazo)-benzenamine

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

para-Dimethylaminoazobenzene (DAB) is carcinogenic in rats, producing liver tumours after its administration by several routes, and in dogs, producing bladder tumours following its administration by the oral route. Results of oral administration studies were doubtful in mice and negative in hamsters and guinea-pigs; but these studies were of short duration, and the adequacy of the dose levels used was not known.

DAB has also been tested by subcutaneous injection in mice, and the results are suggestive of local and hepatic carcinogenicity. Treatment of newborn animals produced systemic carcinogenic effects in mice; the negative results obtained in rats are doubtful, since the period of observation was too short. Skin-painting with DAB produced epidermal tumours in rats but not in mice.

An extensive dose-response study was carried out in rats: the lowest effective dose was 1 mg/rat/day and the highest non-effective dose, 0.3 mg/rat/day.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 21 March 1998




















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