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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

OESTRONE

VOL.: 6 (1974) (p. 123)

5. Summary of Data Reported and Evaluation

(N.B.: This section should be read in conjunction with the section 'General Conclusions on Hormones'.)

5.1 Animal carcinogenicity data

Oestrone was tested orally in mice; by subcutaneous injection and by implantation in mice, rats and hamsters; and by skin-painting in mice. Its administration resulted in an increased incidence of mammary tumours in mice; in pituitary, adrenal and mammary tumours and bladder tumours in association with stones in rats; and in renal tumours in both castrated and intact male hamsters.

Oestrone treatment increased the incidence of mammary tumours in strains of mice having a spontaneous incidence of the tumours which may be related to the presence of a virus. No evidence of a possible role of a virus has been demonstrated in rats.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group. Epidemiological studies on steroid hormones used in oestrogen treatment have been summarized in the section, "Oestrogens and Progestins in Relation to Human Cancer", in this volume.

Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987)


Last updated: 18 March 1998






















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