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Summary of Evaluations Performed by the
Joint FAO/WHO Expert Committee on Food Additives

TILMICOSIN
Chemical names: (10E,12E)-(3R,4S,5S,6R,8R,14R,15R)-14-(6-DEOXY-2,3-DI-O-METHYL-b-d-ALLO-HEXOPYRANOSYOXYMETHYL)-5-(3,6-DIDEOXY-3-DIMETHYLAMINO-b-d-GLUCO- HEXAPYRANOSYLOXY)-6-[2-(cis-3,5-DIMETHYLPIPERIDINO)ETHYL]-3-HYDROXY-4,8,12- TRIMETHYL-9-OXOHEPTADECA-10,12-DIEN-15-OLIDE; 4A-O-DE(2,6-DIDEOXY-3-C-METHYL-alpha-L-RIBO-HEXOPYRANOSYL)-20-DEOXY-20-(3,5-DIMETHYL-1-PIPERIDINYL)-(20(cis:trans))
Synonyms: 20-DEOXY-20-(3,5-DIMETHYLPIPERIDIN-1-YL)-DESMYCOSIN
Functional class: VETERINARY DRUG (ANTIMICROBIAL AGENT)
Latest evaluation: 2000
ADI: 0-0.04 mg/kg bw (1996)
Comments/MRLs: The MRLs (in mg/kg tissue, mg/l milk) recommended at the forty-seventh meeting (1996) for muscle, liver, kidney and fat of cattle, pigs and sheep were not considered at the fifty-fourth meeting (2000) and were maintained; the temporary MRL for sheep milk was not extended as the requested data were not provided.
Report: TRS 900-JECFA 54/29
Residues: FNP 41/13-JECFA 54/124
Tox monograph: FAS 38-JECFA 47/109 (1996)
Previous status: 1996, TRS 876-JECFA 47/37, FNP 41/9-JECFA 47/105, FAS 38-JECFA 47/109. MRLs (EXPRESSED AS PARENT DRUG): MUSCLE (CATTLE, PIGS AND SHEEP): 0.1; LIVER (CATTLE AND SHEEP): 1; LIVER (PIGS): 1.5; KIDNEY (CATTLE AND SHEEP): 0.3; KIDNEY (PIGS): 1; FAT (CATTLE, PIGS AND SHEEP): 0.1; MILK (SHEEP): 0.05 (TEMPORARY). FU. MRL/TMRL
 
12 Nov 01    




    See Also:
       Toxicological Abbreviations
       Tilmicosin (WHO Food Additives Series 38)