IPCS INCHEM Home
ISONIAZID (OBSOLETE)ICSC: 1258 (March 1995)
Isonicotinic hydrazide
4-Pyridinecarboxylic acid
CAS #: 54-85-3
EC Number: 200-214-6

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 PREVENT DISPERSION OF DUST!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation Sore throat. Cough. Nausea. Vomiting. Hallucinations. Tremor.  Use local exhaust or breathing protection.  Fresh air, rest. Refer immediately for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Dizziness. Confusion. Nausea. Vomiting. Weakness. Convulsions. Unconsciousness.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles. 

According to UN GHS Criteria

excl mark;warn
Harmful if swallowed
Causes skin irritation 

Transportation
UN Classification
 

STORAGE
Cool. Well closed. 
PACKAGING
 
ISONIAZID (OBSOLETE) ICSC: 1258
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE ODOURLESS POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. 

Formula: C6H7N3O
Molecular mass: 137.1
Melting point: 170-173°C
Solubility in water, g/100ml at 20°C: 12.5
Flash point: > 250°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Effects of short-term exposure
The substance may cause effects on the nervous system, eyes and kidneys. Exposure at high levels could cause death. Exposure could cause convulsions. The substance is irritating to the eyes, skin and respiratory tract. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions. Repeated or prolonged contact with skin may cause dermatitis. 


OCCUPATIONAL EXPOSURE LIMITS
 

ENVIRONMENT
 

NOTES
Many trade names are known for this compound. 

ADDITIONAL INFORMATION
  EC Classification
 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.


    See Also:
       Toxicological Abbreviations
       Isoniazid (PIM 288)