ICSC 0513 - N-METHYL-2-PYRROLIDONE

N-METHYL-2-PYRROLIDONE	ICSC: 0513 (April 2014)
1-Methyl-2-pyrrolidinone 1-Methyl-2-pyrrolidone N-Methylpyrrolidone NMP

CAS #: 872-50-4

EC Number: 212-828-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 86°C explosive vapour/air mixtures may be formed.	NO open flames. Above 86°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

PREVENT GENERATION OF MISTS!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Headache.	Use local exhaust or ventilation.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Redness. Pain.	Protective gloves. Protective clothing.	Rinse skin with plenty of water or shower.
Eyes	Redness. Pain. Blurred vision.	Wear safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Burning sensation in the throat and chest.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Store and dispose of according to local regulations. Wash away remainder with plenty of water.	According to UN GHS Criteria WARNING Combustible liquid May be harmful if swallowed Causes serious eye irritation May cause respiratory irritation Suspected of damaging fertility or the unborn child Transportation UN Classification
STORAGE
Dry. Ventilation along the floor. Separated from strong oxidants, strong acids, strong bases, copper and plastics.
PACKAGING

N-METHYL-2-PYRROLIDONE

ICSC: 0513

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. It reacts violently with strong acids and strong bases. Attacks copper and its alloys.	Formula: C₅H₉NO Molecular mass: 99.1 Boiling point: 202°C Melting point: -24.4°C Relative density (water = 1): 1.03 Solubility in water: miscible Vapour pressure, Pa at 25°C: 39 Relative vapour density (air = 1): 3.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 86°C c.c. Auto-ignition temperature: 245°C Explosive limits, vol% in air: 1.3-9.5 Octanol/water partition coefficient as log Pow: -0.38 Viscosity: 1.62 mm²/s at 25°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. It reacts violently with strong acids and strong bases. Attacks copper and its alloys.

Formula: C₅H₉NO
Molecular mass: 99.1
Boiling point: 202°C
Melting point: -24.4°C
Relative density (water = 1): 1.03
Solubility in water: miscible
Vapour pressure, Pa at 25°C: 39
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 86°C c.c.
Auto-ignition temperature: 245°C
Explosive limits, vol% in air: 1.3-9.5
Octanol/water partition coefficient as log Pow: -0.38
Viscosity: 1.62 mm²/s at 25°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness.	Inhalation risk A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness.

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

OCCUPATIONAL EXPOSURE LIMITS
EU-OEL: 40 mg/m³, 10 ppm as TWA; 80 mg/m³, 20 ppm as STEL; (skin). MAK: 82 mg/m³, 20 ppm; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C

ENVIRONMENT

NOTES
N-Methyl-2-pyrrolidone enhances the skin permeability for other substances.

ADDITIONAL INFORMATION

EC Classification
R: 61-36/37/38; S: 53-45

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    See Also:
       Toxicological Abbreviations