ICSC 1258 - ISONIAZID(OBSOLETE)

ISONIAZID (OBSOLETE)	ICSC: 1258 (March 1995)
Isonicotinic hydrazide 4-Pyridinecarboxylic acid

CAS #: 54-85-3

EC Number: 200-214-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Cough. Nausea. Vomiting. Hallucinations. Tremor.	Use local exhaust or breathing protection.	Fresh air, rest. Refer immediately for medical attention.
Skin		Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness. Pain.	Wear safety spectacles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Dizziness. Confusion. Nausea. Vomiting. Weakness. Convulsions. Unconsciousness.	Do not eat, drink, or smoke during work.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.	According to UN GHS Criteria Harmful if swallowed Causes skin irritation Transportation UN Classification
STORAGE
Cool. Well closed.
PACKAGING

ISONIAZID (OBSOLETE)

ICSC: 1258

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance WHITE CRYSTALLINE ODOURLESS POWDER. Physical dangers Chemical dangers Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides.	Formula: C₆H₇N₃O Molecular mass: 137.1 Melting point: 170-173°C Solubility in water, g/100ml at 20°C: 12.5 Flash point: > 250°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE ODOURLESS POWDER.

Physical dangers

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides.

Formula: C₆H₇N₃O
Molecular mass: 137.1
Melting point: 170-173°C
Solubility in water, g/100ml at 20°C: 12.5
Flash point: > 250°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by ingestion. Effects of short-term exposure The substance may cause effects on the nervous system, eyes and kidneys. Exposure at high levels could cause death. Exposure could cause convulsions. The substance is irritating to the eyes, skin and respiratory tract.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions. Repeated or prolonged contact with skin may cause dermatitis.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion.

Effects of short-term exposure
The substance may cause effects on the nervous system, eyes and kidneys. Exposure at high levels could cause death. Exposure could cause convulsions. The substance is irritating to the eyes, skin and respiratory tract.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions. Repeated or prolonged contact with skin may cause dermatitis.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
Many trade names are known for this compound.

ADDITIONAL INFORMATION

EC Classification

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    See Also:
       Toxicological Abbreviations
       Isoniazid (PIM 288)