|DIAZOMETHANE||ICSC: 1256 (May 2018)|
| CAS #: 334-88-3
|EC Number: 206-382-7
|ACUTE HAZARDS||PREVENTION||FIRE FIGHTING|
|FIRE & EXPLOSION||Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. Gas/air mixtures are explosive.||NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).||Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. Combat fire from a sheltered position.|
|AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!|
|Inhalation||Sore throat. Headache. Laboured breathing. Shortness of breath. Nausea. Vomiting. Symptoms may be delayed. See Notes.||Use ventilation, local exhaust or breathing protection.||Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.|
|Skin||Redness. Pain. Skin burns. Burning sensation. ON CONTACT WITH LIQUID: FROSTBITE.||Cold-insulating gloves.||ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention. Wear protective gloves when administering first aid.|
|Eyes||Burning sensation. Redness. Pain. Burns. Loss of vision. ON CONTACT WITH LIQUID: FROSTBITE.||Wear face shield or eye protection in combination with breathing protection.||First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Keep rinsing during transport for medical attention.|
|Ingestion||Do not eat, drink, or smoke during work.||Unlikely under occupational conditions.|
|SPILLAGE DISPOSAL||CLASSIFICATION & LABELLING|
|Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.||
According to UN GHS Criteria
DANGERFatal if inhaled
May cause cancer
Causes severe skin burns and eye damage
|Solutions of diazomethane should not be stored. See Notes.|
|PHYSICAL & CHEMICAL INFORMATION|
Physical State; Appearance
|EXPOSURE & HEALTH EFFECTS|
Routes of exposure
Effects of short-term exposure
Effects of long-term or repeated exposure
|OCCUPATIONAL EXPOSURE LIMITS|
TLV: 0.2 ppm as TWA; A2 (suspected human carcinogen).
MAK: carcinogen category: 2
|Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
The relation between odour and the occupational exposure limit cannot be indicated.
The recommendations on this Card also apply to concentrated solutions of diazomethane.
Symbol: T; R: 45; S: 53-45
|All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.|
See Also: Toxicological Abbreviations Diazomethane (IARC Summary & Evaluation, Volume 7, 1974)