ICSC 0209 - ACETIC ANHYDRIDE

ACETIC ANHYDRIDE	ICSC: 0209 (April 2006)
Acetic acid, anhydride Acetic oxide Ethanoic anhydride Acetyl oxide

CAS #: 108-24-7

UN #: 1715

EC Number: 203-564-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Flammable. Above 49°C explosive vapour/air mixtures may be formed.	NO open flames, NO sparks and NO smoking. Above 49°C use a closed system, ventilation and explosion-proof electrical equipment.	Use alcohol-resistant foam, powder, carbon dioxide. See Notes. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Laboured breathing. Shortness of breath. Sore throat.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin	Redness. Skin burns. Pain. Blisters. Symptoms may be delayed.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Watering of the eyes. Redness. Pain. Burns.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal pain. Burning sensation. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Consult an expert! Personal protection: chemical protection suit, face shield and filter respirator for acid gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage Transportation UN Classification UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II
STORAGE
Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry.
PACKAGING
Do not transport with food and feedstuffs.

ACETIC ANHYDRIDE

ICSC: 0209

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers Decomposes on burning. This produces toxic gases and toxic fumes including acetic acid fumes. Reacts violently with alcohols, amines, oxidants, strong bases and water. Attacks many metals in the presence of water or when dry.	Formula: C₄H₆O₃/(CH₃CO)₂O Molecular mass: 102.1 Boiling point: 139°C Melting point: -73°C Relative density (water = 1): 1.08 Solubility in water: reaction Vapour pressure, kPa at 20°C: 0.5 Relative vapour density (air = 1): 3.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 49°C c.c. Auto-ignition temperature: 316°C Explosive limits, vol% in air: 2.7-10.3 Octanol/water partition coefficient as log Pow: -0.27

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
Decomposes on burning. This produces toxic gases and toxic fumes including acetic acid fumes. Reacts violently with alcohols, amines, oxidants, strong bases and water. Attacks many metals in the presence of water or when dry.

Formula: C₄H₆O₃/(CH₃CO)₂O
Molecular mass: 102.1
Boiling point: 139°C
Melting point: -73°C
Relative density (water = 1): 1.08
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 0.5
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 49°C c.c.
Auto-ignition temperature: 316°C
Explosive limits, vol% in air: 2.7-10.3
Octanol/water partition coefficient as log Pow: -0.27

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour and by ingestion. Effects of short-term exposure Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause asthma-like reactions.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Inhalation may cause asthma-like reactions (RADS).

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Effects of short-term exposure
Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause asthma-like reactions.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Inhalation may cause asthma-like reactions (RADS).

OCCUPATIONAL EXPOSURE LIMITS
MAK: 0.42 mg/m³, 0.1 ppm; peak limitation category: I(2); pregnancy risk group: C. TLV: 1 ppm as TWA; 3 ppm as STEL; A4 (not classifiable as a human carcinogen)

ENVIRONMENT

NOTES
Forms acetic acid when mixed with water. Major fires must be extinguished with large amounts of water from a distance.

ADDITIONAL INFORMATION

EC Classification
Symbol: C; R: 10-20/22-34; S: (1/2)-26-36/37/39-45

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.

    See Also:
       Toxicological Abbreviations