ICSC 0028 - 2-CHLORO-1-NITROBENZENE

2-CHLORO-1-NITROBENZENE	ICSC: 0028 (October 2002)
o-Chloronitrobenzene o-Nitrochlorobenzene 1-Chloro-2-nitrobenzene

CAS #: 88-73-3

UN #: 1578

EC Number: 201-854-9

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.	NO open flames. NO contact with flammables. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Shortness of breath. Confusion. Convulsions. Unconsciousness.	Use local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .
Eyes	Redness. Pain.	Wear safety goggles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from combustible substances, reducing agents and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

2-CHLORO-1-NITROBENZENE

ICSC: 0028

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOW-TO-GREEN CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes of nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). The substance is a strong oxidant. It reacts with combustible and reducing materials.	Formula: C₆H₄ClNO₂ Molecular mass: 157.6 Boiling point: 246°C Melting point: 33°C Density: 1.4 g/cm³ Solubility in water: none Vapour pressure, kPa at 20°C: 0.6 Relative vapour density (air = 1): 5.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.03 Flash point: 124°C c.c. Auto-ignition temperature: 487°C Explosive limits, vol% in air: 1.15-13.1 Octanol/water partition coefficient as log Pow: 2.24

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW-TO-GREEN CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes of nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). The substance is a strong oxidant. It reacts with combustible and reducing materials.

Formula: C₆H₄ClNO₂
Molecular mass: 157.6
Boiling point: 246°C
Melting point: 33°C
Density: 1.4 g/cm³
Solubility in water: none
Vapour pressure, kPa at 20°C: 0.6
Relative vapour density (air = 1): 5.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.03
Flash point: 124°C c.c.
Auto-ignition temperature: 487°C
Explosive limits, vol% in air: 1.15-13.1
Octanol/water partition coefficient as log Pow: 2.24

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.	Inhalation risk A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the blood and liver. This may result in the formation of methaemoglobin, anaemia and liver impairment.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the blood and liver. This may result in the formation of methaemoglobin, anaemia and liver impairment.

OCCUPATIONAL EXPOSURE LIMITS
MAK: skin absorption (H); carcinogen category: 3

ENVIRONMENT
The substance is harmful to aquatic organisms.

NOTES
TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) (ACGIH 2004). Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Rinse contaminated clothing with plenty of water because of fire hazard.

NOTES

TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) (ACGIH 2004).
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Rinse contaminated clothing with plenty of water because of fire hazard.

ADDITIONAL INFORMATION

EC Classification

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    See Also:
       Toxicological Abbreviations