VOL.: 71 (1999) (p. 1405)
Chem. Abstr. Name: Sulfuric acid, diethyl ester
There is inadequate evidence for the carcinogenicity in humans of diethyl sulfate.
There is sufficient evidence for the carcinogenicity of diethyl sulfate in experimental animals.
Diethyl sulfate is probably carcinogenic to humans (Group 2A).
In making the overall evaluation, the Working Group took into account that diethyl sulfate is a strong direct-acting alkylating agent which ethylates DNA and that, as a result, it is genotoxic in virtually all test systems examined, including induction of potent effects in somatic and germ cells of mammals exposed in vivo.For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 54 (1992)
See Also: Toxicological Abbreviations Diethyl sulfate (ICSC) Diethyl Sulfate (IARC Summary & Evaluation, Volume 54, 1992)