International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 121)
CAS No.: 6373-74-6
Chem. Abstr. Name: 5-[(2,4-Dinitrophenyl)amino]-2-(phenylamino)benzene-sulfonic acid, monosodium salt

5.1 Exposure data

CI Acid Orange 3 is used to a limited extent as a dye in semi-permanent hair colouring products and in the dyeing of textiles.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Acid Orange 3 was tested for carcinogenicity by gavage in one study in mice and in one study in rats. In mice, there was no significant increase in the incidence of tumours. A significant increase in the incidence of transitional-cell carcinomas of the renal pelvis was observed in female rats given the high dose. The data on high-dose male rats could not be evaluated owing to their poor survival.

5.4 Other relevant data

CI Acid Orange 3 caused renal toxicity in rats and mice. It was mutagenic to bacteria.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Acid Orange 3.

There is limited evidence in experimental animals for the carcinogenicity of CI Acid Orange 3.

Overall evaluation

CI Acid Orange 3 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms

• Acid Fast Yellow AG
• Acid Fast Yellow E 5R
• Acid Leather Light Brown G
• 2-Anilino-5-(2,4-dinitroanilino)benzenesulfonic acid, monosodium salt
• Acid Orange 3
• Acid Yellow E
• Airedale Yellow E
• Amido Yellow E
• Amido Yellow EA
• Amido Yellow EA-CF
• Anthralan Yellow RRT
• CI No. 10385
• Coranil Brown H EPS
• Derma Fur Yellow RT
• Derma Yellow P
• Dimacide Yellow N-5RL
• Duasyn Acid Yellow RRT
• Elbenyl Orange A-3RD
• Erio Fast Yellow AE
• Erio Fast Yellow AEN
• Erio Yellow AEN
• Erionyl Yellow E-AEN
• Fast Light Yellow E
• Fenalan Yellow E
• Heliacid Light Yellow 4R
• Intranyl Orange T-4R
• Kiton Fast Yellow A
• Lanaperl Yellow Brown GT
• Light Fast Yellow ES
• Lissamine Fast Yellow AE
• Lissamine Fast Yellow AES
• Lissamine Yellow AE
• Multacid Yellow 3R
• Multicuer Brown MPH
• Nailamide Yellow Brown E-L
• Nylocrom Yellow 3R
• Nylomine Acid Yellow B-RD
• Nylosan Yellow E-3R
• Polan Yellow E-3R
• Sellacid Yellow AEN
• Sodium 4-(2,4-dinitroanilino)diphenylamine-2-sulfonate
• Solanile Yellow E
• Sulfacid Light Yellow 5RL
• Superian Yellow R
• Tectilon Orange 3GT
• Tertracid Light Yellow 2R
• Unitertracid Light Yellow RR
• Vondacid Fast Yellow AE
• Vondacid Light Yellow AE
• Xylene Fast Yellow ES

    See Also:
       Toxicological Abbreviations