For definition of Groups, see Preamble Evaluation.
VOL.: 50 (1990) (p. 143)
Chem. Abstr. Name: Ethanamine-2-chloro-N,N-bis(2-chloroethyl) hydrochloride
Trichlormethine is a cytostatic agent that has been used since 1946 for the treatment of leukaemia and lymphoma.
Trichlormethine was tested for carcinogenicity by subcutaneous injection in mice and rats. The study in mice was inadequate for evaluation. In rats, trichlormethine induced a high incidence of sarcomas (mostly spindle-cell type) in animals of each sex at the site of subcutaneous injection, as well as a few intestinal adenocarcinomas; neither tumour type was seen in controls.
No data were available to the Working Group.
In single studies, trichlormethine induced dominant lethal mutations in mice and gene mutations in Chinese hamster cells.
There is sufficient evidence for the carcinogenicity of trichlormethine in experimental animals.
No data were available from studies in humans on the carcinogenicity of trichlormethine.
Trichlormethine is possibly carcinogenic to humans (Group 2B).
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluations: Vol. 9 (1975) (p. 229); Suppl. 7 (1987) (p. 73)
Last updated: 11 November 1997
See Also: Toxicological Abbreviations