International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 149)

CAS No.: 2832-40-8
Chem. Abstr. Name: Acetamide, N-{4-[(2-Hydroxy-5-methylphenyl)azo]phenyl}-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Disperse Yellow 3 is a monoazo pigment dye which has been produced in significant quantities since the 1940s to colour fabrics and plastics. There is potentially widespread exposure to Disperse Yellow 3 because of its use in clothing, hosiery and carpets. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

Disperse Yellow 3 was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats. In female mice, it produced increases in the incidences of hepatocellular tumours and malignant lymphomas; in male mice, the incidence of alveolar/bronchiolar adenomas was increased. In rats, it produced an increase in the incidence of hepatocellular adenomas in males.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

In a single study, Disperse Yellow 3 induced sister chromatid exchange but not chromosomal aberrations in Chinese hamster cells in culture. It was mutagenic to mouse cells in culture. Disperse Yellow 3 was mutagenic to bacteria in the presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of Disperse Yellow 3 in experimental animals.

No data were available from studies in humans on the carcinogenicity of Disperse Yellow 3.

Overall evaluation

Disperse Yellow 3 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 8 (1975) (p. 97); Suppl. 7 (1987) (p. 60)


Last updated 01/20/98

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       Toxicological Abbreviations