International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 139)

CAS No.: 2475-45-8
Chem. Abstr. Name: 9,10-Anthracenedione, 1,4,5,8-tetraamino-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Disperse Blue 1 is an aminoanthraquinone-based dyestuff used in hair colour formulations and in colouring fabrics and plastics. No data on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

Disperse Blue 1 was tested for carcinogenicity by oral administration in one strain of mice and in one strain of rats. In mice, it produced an increase in the incidence of alveolar/bronchiolar adenomas and carcinomas (combined) and a marginal increase in the incidence of hepatocellular tumours in treated males. In rats of each sex, it produced transitional-cell papillomas and carcinomas, squamous-cell papillomas and carcinomas, and leiomyomas and leiomyosarcomas of the urinary bladder; in addition, urinary bladder calculi were observed in the groups of rats in which the incidence of urinary bladder neoplasms was increased. In male rats, the incidence of islet-cell adenomas and carcinomas of the pancreas was marginally increased.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

Calculi were observed in the urinary tract of rats and mice given Disperse Blue 1 in the diet. Urinary bladder lesions included epithelial hyperplasia in rats and mice and squamous metaplasia in rats. Hyperplasia of the transitional epithelium of the renal pelvis occurred in rats.

Disperse Blue 1 was mutagenic to bacteria in the presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is sufficient evidence for the carcinogenicity of Disperse Blue 1 in experimental animals.

No data were available from studies in humans on the carcinogenicity of Disperse Blue 1.

Overall evaluation

Disperse Blue 1 is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.


Last updated 01/20/98

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