International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 48 (1990) (p. 73)

CAS No.: 1163-19-5
Chem. Abstr. Name: Benzene, 1,1'-oxybis[2,3,4,5,6-pentabromo]-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Decabromodiphenyl oxide has been produced since the late 1970s as a flame retardant for use in plastics, especially high-impact polystyrene, and to treat textiles, such as automotive fabrics and tents. Occupational exposure to decabromodiphenyl oxide may occur during its production and use. It has also been detected in environmental samples collected near some production facilities.

5.2 Experimental carcinogenicity data

Decabromodiphenyl oxide was tested for carcinogenicity by oral administration in one strain of mice and in two strains of rats. In one study in rats, it induced hepatocellular adenomas in animals of each sex and acinar-cell adenomas of the pancreas and mononuclear-cell leukaemia in males.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

In single studies, decabromodiphenyl oxide did not induce sister chromatid exchange or chromosomal aberrations in Chinese hamster cells in culture or mutations in mouse cells in culture. In one study, decabromodiphenyl oxide was not mutagenic to bacteria in the presence or absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of decabromodiphenyl oxide in experimental animals.

No data were available from studies in humans on the carcinogenicity of decabromodiphenyl oxide.

Overall evaluation

Decabromodiphenyl oxide is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Decabromodiphenyl Oxide  (IARC Summary & Evaluation, Volume 71, 1999)