International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 47 (1989) (p. 231)

CAS No.: 2386-90-5
Chem. Abstr. Name: 2,2'-Oxybis(6-oxabicyclo[3.1.0]hexane)

5. Summary of Data Reported and Evaluation

5.1 Exposures

Bis(2,3-epoxycyclopentyl)ether is a synthetic organic liquid which has been used as a component and modifier of epoxy resins. Measurements of occupational exposure levels have not been reported.

5.2 Experimental carcinogenicity data

Bis(2,3-epoxycyclopentyl)ether was tested for carcinogenicity by skin application in one experiment in two strains of mice, producing a small number of skin tumours in both strains; an increased incidence of lung tumours was observed in females of one strain. Another experiment by skin application in mice was inadequate for evaluation.

5.3 Human darcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

Bis(2,3-epoxycyclopentyl)ether induced sister chromatid exchange in cultured human cells and micronuclei in mice. It was mutagenic to bacteria.

5.5 Evaluation

There is limited evidence for the carcinogenicity of bis(2,3-epoxycyclopentyl)ether in experimental animals.

No data were available from studies in humans on the carcinogenicity of bis(2,3-epoxycyclopentyl)ether.

Overall evaluation

Bis(2,3-epoxycyclopentyl)ether is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Bis(2,3-epoxycyclopentyl)ether  (IARC Summary & Evaluation, Volume 71, 1999)