VOL.: 40 (1986) (p. 245)
Chem. Abstr. Name: 1H-Pyrido[2,3-b]indo1-2-amine
No data were available to evaluate the reproductive effects or prenatal toxicity of this compound to experimental animals.
A-a-C induced prophage in bacteria. It induced DNA damage in Bacillus subtilis and mutations in Salmonella typhimurium in the presence of an exogenous metabolic system. It gave positive results in the wing spot test in Drosophila melanogaster. In cultured Chinese hamster lung cells, A-a-C induced mutations and chromosomal aberrations in the presence and polyploidy in the absence, of an exogenous metabolic system. It induced sister chromatid exchanges in human lymphoblastoid cells.
No data were available on the carcinogenicity of A-a-C to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 2B)
See Also: Toxicological Abbreviations