International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 37 (1985) (p. 233)
CAS No.: 71267-22-6
Chem. Abstr. Name: 2,3'-Bipyridine, 1,2,3,6-tetrahydro-1-nitroso-
5. Summary of Data Reported and Evaluation
N'-Nitrosoanatabine (NAT) has been found in a variety of tobacco
products (snuff, chewing tobacco, cigarettes and cigars), in
mainstream and sidestream smoke from cigars and cigarettes, in saliva
of chewers of betel quid with tobacco and in saliva of users of
chewing tobacco and oral snuff. Some of the NAT in saliva appears to
be formed endogenously from nitrite in saliva and tobacco alkaloids.
Thus, there is widespread exposure to NAT among users of tobacco
products and those exposed to sidestream smoke.
5.2 Experimental data
NAT was tested for carcinogenicity by subcutaneous injection in
rats of one strain at three dose levels. There was no increase in
No data were available on mutagenic or related effects of NAT.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
NAT was available to the Working Group.
The available data are inadequate to evaluate the carcinogenicity
of N'-nitrosoanatabine to experimental animals.
No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)
Last updated: 21 April 1998