International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 343)

CAS No.: 191-30-0
Chem. Abstr. Name: Dibenzo(def,p)chrysene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenzo[a,l]pyrene was tested for carcinogenicity in mice in one study by skin application and in one study by subcutaneous administration. It induced tumours at the sites of application.

No data on the teratogenicity of this compound were available.

No data were available to evaluate the activity of dibenzo[a,l]pyrene in short-term tests.

5.2 Human data

Dibenzo[a,l]pyrene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to dibenzo[a,l]pyrene occurs mainly through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

There is sufficient evidence that dibenzo[a,l]pyrene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)


Last updated: 17 April 1998

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       Toxicological Abbreviations