VOL.: 32 (1983) (p. 337)
Chem. Abstr. Name: Benzo(rst)pentaphene
No data on the teratogenicity of this compound were available.
Dibenzo[a,i]pyrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It was positive in assays for differential killing in strains of DNA-repair-proficient/-deficient bacteria. It did not induce unscheduled DNA synthesis in rat hepatocytes.
There is inadequate evidence that dibenzo[a,i]pyrene is active in short-term tests.
N.B. - Studies on occupational exposure to polynuclear aromatic compounds will be considered in future IARC Monographs.
N.B. - In the absence of adequate data on humans,it is reasonable, for practical purposes, to consider chemicals for which there is sufficient evidence of carcinogenicity in animals as if they presented a carcinogenic risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)
See Also: Toxicological Abbreviations