International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 327)
CAS No.: 192-65-4
Chem. Abstr. Name: Naphtho(1,2,3,4-def)chrysene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Dibenzo[a,e]pyrene has been shown to be carcinogenic to
No data on the teratogenicity of this compound were available.
In the one study evaluated, dibenzo[a,e]pyrene was mutagenic to
Salmonella typhimurium in the presence of an exogenous metabolic
There is inadequate evidence that dibenzo[a,e]pyrene is active in
5.2 Human data
Dibenzo[a,e]pyrene is present as a minor component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to dibenzo[a,e]pyrene occurs primarily through the smoking of
tobacco, inhalation of polluted air and by ingestion of food and water
contaminated with combustion products.
There is sufficient evidence that dibenzo[a,e]pyrene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)
Last updated: 17 April 1998