International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 195)

CAS No.: 191-24-2
Chem. Abstr. Name: Benzo(ghi)perylene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[ghi]perylene was tested for carcinogenicity in two studies by skin application to female mice, and no carcinogenic effect was observed. It was tested in three studies in the mouse-skin initiation-promotion assay, also with negative results. In two studies in mice by subcutaneous injection, no tumour was observed at the injection site. The results of a test using intrapulmonary injection in rats were inadequate for evaluation, although some pulmonary tumours occurred. When benzo[ghi]perylene was administered simultaneously with benzo[a]pyrene to the skin of mice, an increased number of skin tumours was observed over that with benzo[a]pyrene alone.

No data on teratogenicity of this compound were available.

Benzo[ghi]perylene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It was negative in one study of morphological transformation in mammalian cells.

There is inadequate evidence that benzo[ghi]perylene is active in short-term tests.

5.2 Human data

Benzo[ghi]perylene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[ghi]perylene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

The available data were inadequate to permit an evaluation of the carcinogenicity of benzo[ghi]perylene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)


Last updated: 17 April 1998

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       Toxicological Abbreviations