International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 123)

CAS No.: 225-11-6
Chem. Abstr. Name: Benz(a)acridine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benz[a]acridine was inadequately tested for carcinogenicity in one experiment by skin application to mice. No data on the teratogenicity of this compound were available.

The single report of the mutagenicity of benz[a]acridine in Salmonella typhimurium was inconclusive.

There is inadequate evidence that benz[a]acridine is active in short-term tests.

5.2 Human data

Benz[a]acridine is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benz[a]acridine occurs primarily through inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

The available data are inadequate to permit the evaluation of the carcinogenicity of benz[a]acridine in experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)


Last updated: 17 April 1998

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       Toxicological Abbreviations