Chlorobenzilate (IARC Summary & Evaluation, Volume 30, 1983)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CHLOROBENZILATE

VOL.: 30 (1983) (p. 73)

CAS No.: 510-15-6
Chem. Abstr. Name: Benzeneacetic acid, 4-chloro-a-(4-chlorophenyl)- a-hydroxy-, ethyl ester

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Chlorobenzilate was tested for carcinogenicity by administration in the diet in three strains of mice and in two strains of rats. It induced hepatocellular carcinomas in both sexes of mice of one strain and in males of the two other strains. The data on rats were inadequate for evaluation.

Although no adverse effect was observed on reproduction in a three-generation study of rats, the teratogenic potential of chlorobenzilate has not been fully determined.

Chlorobenzilate was not mutagenic to Salmonella typhimurium with or without exogenous metabolic activation. Data from studies on other organisms were considered insufficient for evaluation, and no overall evaluation of the mutagenicity of chlorobenzilate could be made.

5.2 Human data

Chlorobenzilate was introduced in 1952. Its production, formulation and use as an acaricide on citrus and other crops are sources of potential exposure, both of workers and of the general population.

No data were available to evaluate the teratogenic or chromosomal effects of chlorobenzilate in humans.

No case report or epidemiological study of the carcinogenicity of chlorobenzilate alone was available to the Working Group. (See, however, the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)

5.3 Evaluation

Results of the experiments in mice provide limited evidence that chlorobenzilate is carcinogenic to experimental animals. No data on humans were available.

The available data are insufficient to evaluate the carcinogenicity of chlorobenzilate to humans.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 5 (1974)

Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3)

Synonyms

Acar
Acaraben
Acaraben 4E, 250 EC, 500 EC, 25 WP
Chlorbenzilat
Chlorbenzilate
Chlorbenzylate
4,4'-Dichlorobenzilate
4,4'-Dichlorobenzilic acid ethyl ester
ENT 18596
Ethyl 4-chloro-a-(4-chlorophenyl)-a-hydroxybenzeneacetate
Ethyl para,para'-dichlorobenzilate
Ethyl 4,4'-dichlorodiphenyl glycollate
Ethyl 4,4'-dichlorophenyl glycollate
Ethyl di(para-chlorophenyl)glycollate
Ethyl 2-hydroxy-2,2-bis(3-chlorophenyl)acetate
NCI-C00408

Last updated: 16 April 1998





























    See Also:
       Toxicological Abbreviations
       Chlorobenzilate (ICSC)
       Chlorobenzilate (FAO Meeting Report PL/1965/10/1)
       Chlorobenzilate (FAO/PL:1968/M/9/1)
       Chlorobenzilate (WHO Pesticide Residues Series 2)
       Chlorobenzilate (WHO Pesticide Residues Series 5)
       Chlorobenzilate (Pesticide residues in food: 1977 evaluations)
       Chlorobenzilate (Pesticide residues in food: 1980 evaluations)
       Chlorobenzilate (IARC Summary & Evaluation, Volume 5, 1974)