International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 29 (1982) (p. 193)

CAS No.: 85-68-7
Chem. Abstr. Name: 1,2-Benzenedicarboxylic acid, butyl

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Butyl benzyl phthalate was tested in mice and female rats by oral administration and in male mice by intraperitoneal injection. A somewhat higher incidence of monocytic leukaemias was observed in female rats. In mice, no increased incidence of tumours was observed.

Butyl benzyl phthalate was not mutagenic for Escherichia coli, Bacillus subtilis, Salmonella typhimurium or Saccharomyces cerevisiae or in the mouse lymphoma assay.

No data were available to assess the teratogenicity of this compound to experimental animals.

5.2 Human data

Occupational exposure to butyl benzyl phthalate has and probably still does occur during its manufacture, its use as a plasticizer and in the further processing or use of plasticized products containing it.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

The available studies were inadequate to evaluate the carcinogenicity of butyl benzyl phthalate to mice and rats.

No case report or epidemiological study was available.

No evaluation could be made of the carcinogenic risk to man of butyl benzyl phthalate.

Subsequent evaluations: Suppl. 7 (1987) (p. 59: Group 3); Vol. 73 (1999)


Last updated" 9 April 1998

    See Also:
       Toxicological Abbreviations
       Butyl benzyl phthalate (ICSC)
       Butyl benzyl phthalate (CICADS 17, 1999)
       Butyl Benzyl Phthalate  (IARC Summary & Evaluation, Volume 73, 1999)