VOL.: 26 (1981) (p. 203)
Dacarbazine can induce teratogenic effects in several species. It is mutagenic in mammalian cells in culture.
The available data are insufficient to evaluate the teratogenicity, mutagenicity or chromosomal effects of dacarbazine in humans.
A single case of acute leukaemia following treatment with dacarbazine in combination with other cytotoxic agents has been reported. The only epidemiological study was small and of short duration and showed no excess of subsequent neoplasms in patients treated with a regimen consisting of dacarbazine, adriamycin, bleomycin and vinblastine.
This chemical should be regarded for practical purposes as if it presented a carcinogenic risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Dacarbazine (IARC Summary & Evaluation, Supplement7, 1987)