International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2,4,5-T and ESTERS

VOL.: 15 (1977) (p. 273)

5. Summary of Data Reported and Evaluation

5.1 Animal data

2,4,5-T was tested in mice in three studies by oral and subcutaneous administration. All of these studies had limitations due to the small numbers of animals used. Therefore, although an increased incidence of tumours at various sites was observed in one study in which 2,4,5-T (containing less than 0.05 ppm chlorinated dibenzodioxins) was given orally, no evaluation of the carcinogenicity of this compound could be made on the basis of the available data.

5.2 Human data

The results of the single cohort study of a small number of workers exposed to various herbicides, including 2,4-D, 2,4,5-T and 3-amino-1,2,4-triazole (amitrole) (see IARC, 1976, Vol. 41), are not sufficient to evaluate the carcinogenicity of 2,4,5-T to man (Because 2,4,5-T is contaminated with 2,3,7,8-tetrachlorodibenzo-para-dioxin, see also monograph on chlorinated dibenzodioxins; IARC, 1997 - Vol. 69).

Subsequent evaluations: Vol. 41 (1986) (Chlorophenoxy herbicides, Occupational exposures to); Suppl. 7 (1987) (Chlorophenoxy herbicides)

Last updated: 26 March 1998

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