International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 11 (1976) (p. 225)

CAS No.: 3068-88-0
Chem. Abstr. Name: 4-Methyl-2-oxetanone

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

b-Butyrolactone is carcinogenic in mice by skin application and by subcutaneous injection and in rats by oral administration and by subcutaneous injection. It produced tumours at the site of administration in both species.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Vol. 71 (1999)


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Butyrolactone, beta-  (IARC Summary & Evaluation, Volume 71, 1999)