International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 10 (1976) (p. 269)
CAS No.: 15503-86-3
Chem. Abstr. Name: 12,18-Dihydroxysenecionan-11,16-dione-4-oxide
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Isatidine is carcinogenic in rats as shown by a limited study in which
it produced liver tumours following its oral administration (see also
section "General Information and Conclusions on Pyrrolizidine
Alkaloids", in this volume).
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)
For definition of Groups, see Preamble Evaluation.
- Retrorsine N-oxide
Last updated: 22 March 1998