International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 10 (1976) (p. 99)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
There are no adequate feeding studies with pure cholesterol available
to evaluate its carcinogenicity. Experiments involving subcutaneous
injection of cholesterol in various vehicles cannot be evaluated
because of variations in parameters unrelated to the dose of
cholesterol administered. Implantation experiments using cholesterol
are difficult to interpret, because the effects of the physical
factors must be taken into consideration.
On the basis of the experimental evidence available no assessment of
the carcinogenicity of cholesterol is possible.
5.2 Human carcinogenicity data
No data are available to assess the carcinogenicity of exogenous
cholesterol in man. Studies of cancer in relation to dietary fat,
serum cholesterol levels and the degradation of biliary steroids are
not directly relevant to this question.
Subsequent evaluations: Vol 31 (1983);
Suppl. 7 (1987)
Last updated: 22 March 1998