International Agency for Research on Cancer (IARC) - Summaries & Evaluations
NITROGEN MUSTARD N-OXIDE (HYDROCHLORIDE)
VOL.: 9 (1975) (p. 209)
CAS No.: 126-85-2
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanamine-N-oxide
CAS No.: 302-70-5
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanamine-N-oxide hydrochloride
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Nitrogen mustard N-oxide hydrochloride is carcinogenic in mice and
rats. Following its subcutaneous injection in mice, it produced lung
tumours, thymic lymphomas and Harderian gland adenomas; following its
intravenous injection in rats it produced mainly lymphoreticular
tumours and sarcomas.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)
For definition of Groups, see Preamble Evaluation.
Synonyms for Nitrogen mustard N-oxide
- 2,2'-Dichloro-N-methyldiethylamine-N-oxide
- HN2 oxide mustard
- MBAO
- Mechlorethamine oxide
- Methylbis(b-chloroethyl)amine-N-oxide
- Nitrogen mustard amine oxide
- Nitrogen mustard oxide
- Nitrogen mustard N-oxide
- NMO
- Oxy-NH2
Synonyms for Nitrogen mustard N-oxide (hydrochloride)
- 2,2'-Dichloro-N-methyldiethylamine N-oxide hydrochloride
- Mechlorethamine oxide hydrochloride
- Methylbis(2-chloroethyl)amine N-oxide hydrochloride
- Methylbis(b-chloroethyl)amine N-oxide hydrochloride
- N-Methylbis(b-chloroethyl)amine N-oxide hydrochloride
- N-Methyl-2,2'-dichlorodiethylamine N-oxide hydrochloride
- Methyldi(2-chloroethyl)amine N-oxide hydrochloride
- Mitomen
- Mustron
- Nitrogen mustard oxide
- Nitrogen mustard N-oxide
- Nitrogen mustard N-oxide hydrochloride
- Nitromin
- Nitromin hydrochloride
- N-Oxide-Lost
- NSC-10107
- SK-598
Last updated: 21 March 1998