VOL.: 6 (1974) (p. 149)
Given alone, it produced no increase in the incidence of tumours in mice or in rats but resulted in mammary tumours in dogs. The significance of the tumours in dogs is discussed in the section, "General Remarks on the Sex Hormones", in this volume.
In combination with mestranol, the incidence of pituitary tumours was increased in mice of both sexes; in combination with ethinyloestradiol, it increased the incidence of mammary tumours in intact and castrated males of one hybrid strain.
Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987) (Progestins; Combined oral contraceptives)
See Also: Toxicological Abbreviations Chlormadinone Acetate (IARC Summary & Evaluation, Volume 21, 1979)