International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 1 (1972) (p. 80)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Benzidine is carcinogenic in the mouse, rat and hamster, and possibly
the dog. Given orally, it has produced bladder carcinoma in the dog
after a long latent period and liver tumours in the rat and hamster.
5.2 Human carcinogenicity data
The epidemiological studies showed that occupational exposure to
commercial benzidine alone was strongly associated with bladder
cancer. In the same studies, exposure to 2-naphthylamine alone was
similarly associated with bladder cancer. A number of case reports
from several countries support the relationship between this neoplasm
and occupational exposure to benzidine.
Vol. 29 (1982); Suppl. 7 (1987)
Last updated: 12 March 1998