International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 1 (1972) (p. 74)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

4-Aminobiphenyl is carcinogenic in the mouse, rat, rabbit and dog. Following its oral administration it has produced bladder and liver tumours in mice and bladder papillomas and carcinomas in rabbits and dogs.

5.2 Human carcinogenicity data

In the epidemiological studies, confined to one series of workers occupationally exposed to commercial 4-aminobiphenyl, a high incidence of bladder carcinomas was reported. In consequence one can say that bladder cancer was strongly associated with occupational exposure to 4-aminobiphenyl.

Subsequent evaluation: Suppl. 7 (1987)

Last updated: 12 March 1998

    See Also:
       Toxicological Abbreviations
       Aminobiphenyl, 4-  (IARC Summary & Evaluation, Supplement7, 1987)