International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

Supplement 7: (1987) (p. 347)

CAS No.: 127-69-5

Chem. Abstr. Name: Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-

A. Evidence for carcinogenicity to humans (inadequate)

No significant association with cancer at any site was oberved during 1969-1976 among 11 659 members of a prepaid health plan prescribed sulfafurazole during 1969-1973 [ref: 1].

B. Evidence for carcinogenicity to animals (inadequate)

Sulfafurazole was tested in mice and rats by oral administration; no increase in tumour incidence was observed [ref: 2].

C. Other relevant data

No data were available to the Working Group.

Overall evaluation

Sulfafurazole (sulphisoxazole) is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Also see previous evaluation: Vol. 24 (1980)


1. Friedman, G.D. & Ury, H.K. (1980) Initial screening for carcinogenicity of commonly used drugs. J. natl Cancer Inst., 65, 723-733

2. IARC Monographs, 24, 275-285, 1980


Last updated: 11 March 1998

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       Toxicological Abbreviations