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    Annex 4: Recommendations on compounds on the agenda

                                                                                                  
    Substance                  Acceptable daily       Recommended maximum residue limit
                            intake (ADI) and other    (MRL)
                                 toxicological
                                recommendations
                                                                                              

    -Adrenoceptor-blocking agent

      Carazolol               0-0.1 g per kg of      Muscle & fat/skin (pigs): 5 g/kga,b
                                  body weight         Liver & kidney (pigs): 25 g/kga,b

    Antimicrobial agents

      Dihydrostreptomycin      0-30 g per kg of      Muscle, liver & fat (cattle, pigs,
      & streptomycin            body weightc,d          chickens & sheep): 500 g/kge,f
                                                      Kidney (cattle, pigs, chickens & sheep):
                                                        1000 g/kge,f
                                                      Milk (cattle): 200 g/le,f

      Enrofioxacin            0-0.6 g per kg of      No MRLs recommendedg
                                 body weightc

      Gentamicin               0-4 g per kg of       Muscle & fat (cattle & pigs): 100 g/kga,e
                                 body weightc         Liver (cattle & pigs): 200 g/kga,e
                                                      Kidney (cattle & pigs): 1000 g/kga,e
                                                      Milk (cattle): 100 g/la,e

      Neomycin                 0-30 g per kg of      Muscle, liver & fat (cattle, chickens, ducks,
                                 body weightc           goats, pigs, sheep & turkeys): 500 g/kga,h
                                                      Kidney (cattle, chickens, ducks, goats, pigs,
                                                        sheep & turkeys): 5000 g/kga,h
                                                      Eggs (chickens): 500 g/kga,h
                                                      Milk (cattle): 500 g/la,h

      Oxolinic acid            No ADI allocatedi      No MRLs recommendedj

      Spiramycin               0-50 g per kg of      Muscle (cattle): 100 g/kgk
                                  body weight         Muscle (pigs & chickens): 200 g/kgk
                                                      Liver (cattle): 300 g/kgk
                                                      Liver (pigs): 600 g/kge,k
                                                      Liver (chickens): 400 g/kgk
                                                      Kidney (cattle): 200 g/kgk
                                                      Kidney (pigs): 300 g/kge,k
                                                      Kidney (chickens): 800 g/kgk
                                                      Fat (cattle): 300 g/kgk
                                                      Fat (pigs): 200 g/kge,k
                                                      Fat (chickens): 300 g/kgk
                                                      Milk (cattle): 100 g/lk

                                                                                              
    Substance                  Acceptable daily       Recommended maximum residue limit
                            intake (ADI) and other    (MRL)
                                 toxicological
                                recommendations
                                                                                              

    Glucocorticosteroid

      Dexamethasone        0-0.015 g per kg of       Muscle & kidney (cattle, horses & pigs):
                                 body weightl           0.5 g/kga,e,m
                                                      Liver (cattle, horses & pigs): 2.5 g/kga,e,m
                                                      Milk (cattle): 0.3 g/la,e,m

    Tranquilizer

      Azaperone                0-3 g per kg of       Muscle & fat (pigs): 60 g/kgh,n
                                 body weightc         Liver & kidney (pigs): 100 g/kgh,n

                                                                                              

    NOTES

    a    Expressed as parent drug.

    b.   The Committee noted that the concentration of carazolol at the
         injection site may exceed the ADI, which is based on the acute
         pharmacological effects of carazolol.

    c.   Temporary ADI.

    d.   Group temporary ADI for dihydrostreptomycin and steptomycin,
         either singly or in combination.  Temporary MRL.

    f.   Expressed as the sum of dihydrostreptomycin and streptomycin.

    g.   The ADI for enrofioxacin is based on antimicrobial activity. MRLs
         were not recommended because the relationship between total
         antimicrobial activity and residues of enrofioxacin and
         ciprofloxacin could not be determined.

    h    Temporary MRLs were recommended because the ADI is temporary.

    i.   An ADI could not be established for oxolinic acid because of
         major reporting and protocol deficiencies in the available
         studies and because a clear no-observed-effect level (NOEL) could
         not be identified for arthropathy in dogs.

    j.   MRLs were not recommended for oxolinic acid because an ADI was
         not established.

    k.   Expressed as the sum of spiramycin and neospiramycin. MRLs in pig
         muscle and temporary MRLs in pig liver, kidney, and fat are based
         on total antimicrobially-active residues and expressed as
         spiramycin equivalents

    I.   The ADI for dexamethasone was established at the forty-second
         meeting of the Committee.

    m.   The MRLs for dexamethasone in cattle and pigs were recommended at
         the forty-second meeting of the Committee.

    n.   Expressed as the sum of azaperone and azaperol.





















    See Also:
       Toxicological Abbreviations