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    INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION





    SAFETY EVALUATION OF CERTAIN 
    FOOD ADDITIVES



    WHO FOOD ADDITIVES SERIES: 42





    Prepared by the Fifty-first meeting of the Joint FAO/WHO
    Expert Committee on Food Additives (JECFA)





    World Health Organization, Geneva, 1999
    IPCS - International Programme on Chemical Safety

    ANNEX 2

    ABBREVIATIONS USED IN THE MONOGRAPHS

    ADI        acceptable daily intake
    Aus-NZ     Australia-New Zealand
    BHA        butylated hydroxyanisole
    BHT        butylated hydroxytoluene
    bw         body weight
    CCFAC      Codex Committee on Food Additives and Contaminants
    CoA        coenzyme A
    DMBA       7,12-dimethylbenz [a]anthracene
    DMSO       dimethyl sulfoxide
    EU         European Union
    F          female
    F0         parental generation
    F1         first filial generation
    F2         second filial geneartion
    F3         third filial generation
    FAO        Food and Agricultural Organization of the United Nations
    FBS        food balance sheet
    FEV1       forced expiratory volume in 1 s
    FSDU       foods for special dietary uses
    GLP        good laboratory practice
    GSFA       General Standard for Food Additives
    HES        household economic survey
    HPLC       high-performance liquid chromatography
    IC50       median inhibitory concentration
    Ig         immunoglobulin
    JECFA      Joint FAO/WHO Expert Committee on Food Additives
    LC50       median lethal concentration
    LD5-35     dose that is lethal to 5-35% of animals
    LD50       median lethal dose
    M          male
    MNNG        N-methyl- N'-nitro- N-nitrosoguanidine
    MRCA       Market Research Corporation of America
    NADP       nicotinamide adenine dinucleotide phosphate
    NADPH      reduced form of NADP
    ND         not determined
    N/D        no intake data reported
    NFCS       National Food Consumption Survey
    NOEL       no-observed-effect level
    NR         not reported
    N/R        not required for evaluation
    OECD       Organisation for Economic Co-operation and Development
    PAPS       3'-phosphoadenosine-5'-phosphosulfate
    PCR        polymerase chain reaction
    PhIP       2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine
    QA         quality assurance
    RP         reverse phase
    S9         hepatic microsome fraction
    S13        hepatic microsome and cytosol fraction

    TBHQ        tert-butylhydroquinone
    TOS        total organic solids
    TPA        12- O-tetradecanoylphorbol 13-acetate
    UDPGT      UDP-glucuronosyltransferase
    USDA       US Department of Agriculture
    





















    See Also:
       Toxicological Abbreviations