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Summary of Evaluations Performed by the
Joint FAO/WHO Expert Committee on Food Additives

SPIRAMYCIN
Chemical names: SPIRAMYCIN
Synonyms: FOROMACIDIN; SEQUAMYCIN; SELECTOMYCIN; ROVAMYCIN; PROVAMYCIN
Functional class: VETERINARY DRUG (ANTIMICROBIAL AGENT)
Latest evaluation: 1997
ADI: 0-0.05 mg/kg bw (1994)
Comments/MRLs: MRLs (in mg/kg tissue, mg/l milk): Muscle (cattle, chickens and pigs): 0.2; Liver (cattle, chickens and pigs): 0.6; Kidney (cattle and pigs): 0.3; Kidney (chickens): 0.8; Fat (cattle, pigs and chickens): 0.3; Milk (cattle): 0.2. For cattle and chickens, MRLs are expressed as the sum of the concentrations of spiramycin and neospiramycin. MRLs for pigs are based on total antimicrobially active residues and expressed as spiramycin equivalents. Except for milk, all MRLs were established at the 47th meeting (1996).
Report: TRS 879-JECFA 48/44
Residues: FNP 41/10-JECFA 48/77
Tox monograph: FAS 34-JECFA 43/143 (1994)
Previous status: 1996, TRS 876-JECFA 47/27, FNP 41/9-JECFA 47/77, FAS 34-JECFA 43/143 (1994). 0-0.05 (1994). MRLs: MUSCLE (CATTLE, PIGS AND CHICKENS): 0.2; LIVER (CATTLE, PIGS AND CHICKENS): 0.6; KIDNEY (CATTLE AND PIGS): 0.3; KIDNEY (CHICKENS): 0.8; FAT (CATTLE, PIGS AND CHICKENS): 0.3; MILK (CATTLE): 0.1. FOR CATTLE AND CHICKENS, MRLs ARE EXPRESSED AS THE SUM OF THE CONCENTRATIONS OF SPIRAMYCIN AND NEOSPIRAMYCIN. MRLs FOR PIGS ARE BASED ON TOTAL ANTIMICROBIALLY ACTIVE RESIDUES AND EXPRESSED AS SPIRAMYCIN EQUIVALENTS. FU. MRL
1994, TRS 855-JECFA 43/38, FNP 41/7-JECFA 43/89, FAS 34-JECFA 43/143, 0-0.05. MRLs: MUSCLE, MILK (CATTLE): 0.1; MUSCLE (PIGS AND CHICKENS), KIDNEY (CATTLE): 0.2; LIVER (CATTLE); FAT (CATTLE AND CHICKENS): 0.3; LIVER (CHICKENS): 0.4; KIDNEY (CHICKENS): 0.8; TEMPORARY MRLs: LIVER (PIGS): 0.6; KIDNEY (PIGS): 0.3; FAT (PIGS): 0.2 (FOR CATTLE AND CHICKENS, MRLs ARE EXPRESSED AS THE SUM OF THE CONCENTRATIONS OF SPIRAMYCIN AND NEOSPIRAMYCIN. MRLs FOR PIG MUSCLE AND TEMPORARY MRLs FOR PIG LIVER, KIDNEY AND FAT ARE BASED ON TOTAL ANTIMICROBIALLY ACTIVE RESIDUES AND EXPRESSED AS SPIRAMYCIN EQUIVALENTS). FU. MRL/TMRL
1991, TRS 815-JECFA 38/31, FNP 41/4-JECFA 38/97, FAS 29-JECFA 38/109. 0-0.005 (TEMPORARY). MRLs (TEMPORARY): MUSCLE (CATTLE AND PIGS): 0.05; LIVER (CATTLE AND PIGS): 0.3; KIDNEY (CATTLE AND PIGS: 0.2; MILK (CATTLE): 0.15
1968, NMRS 45/TRS 430-JECFA 12/18, FAS 69.34/NMRS 45A-JECFA 12/22, NMRS 45/TRS 430-JECFA 12/18. ACCEPTABLE LEVELS OF RESIDUES: MEAT: 0-0.025. NO. N
 
12 Nov 01    




    See Also:
       Toxicological Abbreviations
       Spiramycin (WHO Food Additives Series 29)
       Spiramycin (WHO Food Additives Series 34)