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2-BUTYNE-1,4-DIOL
ICSC: 1733
Peer-Review Status: 13.11.2008 Validated
1,4-Dihydroxy-2-butyne
But-2-yne-1,4-diol
2-Butynediol
1,4-Butynediol
CAS #: 110-65-6 RTECS #: ES0525000
UN #: 2716
EC #: 603-076-00-9
EINECS #: 203-788-6
    Formula: C4H6O2/OHCH2CCCH2OH
Molecular mass: 86.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, alcohol-resistant foam, dry powder, carbon dioxide. 
EXPLOSION Risk of explosion on contact with bases, oxidizing agents or halogens.     
 
EXPOSURE   STRICT HYGIENE!   
Inhalation Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.  Use ventilation (not if powder).  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin Redness. Pain. Skin burns.  Protective clothing. Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. 
Eyes Redness. Pain. Burns.  Wear face shield or eye protection in combination with breathing protection if powder.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: C, T; R: 21-23/25-34-43-48/22; S: (1/2)-25-26-36/37/39-45-46 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic if swallowed
Harmful in contact with skin
Toxic if inhaled (mist)
Causes severe skin burns and eye damage
May cause allergic skin reaction
May cause damage to liver, kidneys and blood through prolonged or repeated exposure
Harmful to aquatic life 
corrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III.  Separated from incompatible materials. See Chemical Dangers. Cool. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
YELLOW SOLID IN VARIOUS FORMS. 

Physical dangers
No data. 

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes. Reacts violently with anhydrides, acid chlorides, mercury salts and alkaline hydroxides or chlorides. This generates explosion hazard. 

Occupational exposure limits
TLV not established.
MAK (inhalable fraction): 0.2 mg/m³; Peak limitation category: I(1); Pregnancy risk group: C; Skin absorption (H); Sensitization of skin (SH); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
Corrosive. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia. The substance may have effects on the kidneys and liver. This may result in tissue lesions. Repeated or prolonged contact may cause skin sensitization. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: No boiling point at normal pressure; decomposes at >160°C
Melting point: 58°C
Relative density (water = 1): 1.1
Solubility in water, g/100ml at 20°C: 75 (good)
Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 3.0
Flash point: 152°C
Auto-ignition temperature: 335°C
Octanol/water partition coefficient as log Pow: -0.73  
The substance is harmful to aquatic organisms. 

NOTES
There is no odour warning even when toxic concentrations are present.
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
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    See Also:
       Toxicological Abbreviations