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DIMETHYL FUMARATE
ICSC: 1732
Peer-Review Status: 08.06.2012 validated
Dimethyl (E)-butenedionate
Boletic acid dimethyl ester
trans-1,2-Ethylenedicarboxylic acid dimethyl ester
2-Butenedioic acid, dimethylester 
CAS #: 624-49-7 EC #: 210-849-0
    Formula: C6H8O4
Molecular mass: 144.13

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, foam, powder, alcohol-resistant foam. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Prevent build-up of electrostatic charges (e.g., by grounding).  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation Cough. Sore throat.  Avoid inhalation of dust.  Fresh air, rest. Seek medical attention if you feel unwell. 
Skin Redness.  Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention if skin irritation occurs. 
Eyes Redness. Pain.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Flushing of the face. Nausea. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
 
GHS Classification
Signal: Warning
Causes serious eye irritation
Harmful in contact with skin
May be harmful if swallowed
May cause an allergic skin reaction 
excl mark;warn

EMERGENCY RESPONSE SAFE STORAGE
  Keep in a well-ventilated room. Well closed. Keep in the dark. Separated from strong oxidants. 

IMPORTANT DATA
Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. 

Chemical dangers
Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light. 

Occupational exposure limits
TLV not established.
MAK (not established):.
EU OEL:. 

Routes of exposure
The substance can be absorbed into the body by ingestion and through the skin. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance is irritating to the skin and respiratory tract. The substance is severely irritating to the eyes. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 193°C
Density: 1.37 g/cm³
Melting point: 104°C
Vapour pressure: negligible
Relative density (water = 1): 1.4
Relative vapour density (air = 1): 5
Solubility in water, g/l: poor (1.6 g/l)
Octanol/water partition coefficient as log Pow: 0.74 (estimated) 
 

NOTES
Products containing more than 0.1% Dimethylfumarate are banned from the market in EU countries. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations