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TETRAHYDROPHTHALIC ANHYDRIDE
ICSC: 1372
Peer-Review Status: 14.03.2001 Validated
4-Cyclohexene-1,2-dicarboxylic anhydride
3a,4,7,7a-Tetrahydro-1,3-isobenzofurandione
THPA
1,2,3,6-Tetrahydrophthalic anhydride 
CAS #: 85-43-8 RTECS #: GW5775000
UN #: 2698
EC #: 607-099-00-5
EINECS #: 201-605-4
    Formula: C8H8O3 / C6H8(CO)2O
Molecular mass: 152.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation Cough. Sore throat. Wheezing. Shortness of breath.  Use local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Redness. Burning sensation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain. Blurred vision. Severe deep burns.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Burning sensation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: Xn; R: 41-42/43-52/53; S: (2)-22-24-26-37/39-61; Note: C 
UN Classification
UN Hazard Class: 8; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-80G09C.  Separated from food and feedstuffs. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on contact with hot surfaces or flames. This produces corrosive fumes. Reacts with oxidants. Reacts with water. This produces heat and tetrahydrophthalic acid. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 6.7kPa: 195°C
Melting point: 102°C
Density: 1.4 g/cm³
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 1
Relative vapour density (air = 1): 5.3
Flash point: 157°C o.c.
Auto-ignition temperature: 450°C  
The substance is harmful to aquatic organisms. 

NOTES
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
For cis-isomer the CAS number is 935-79-5. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations