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METHOXYCHLOR
ICSC: 1306
Peer-Review Status: 26.03.1999 Validated
1,1-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)
1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane
Dimethoxy-DDT 
CAS #: 72-43-5 RTECS #: KJ3675000
EINECS #: 200-779-9
    Formula: C16H15Cl3O2
Molecular mass: 345.7

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation See Ingestion.  Use local exhaust or breathing protection.  Fresh air, rest. 
Skin   Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes   Wear safety spectacles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Convulsions. Diarrhoea. Nausea. Vomiting.  Do not eat, drink, or smoke during work. Wash hands before eating.  Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-LIGHT-YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic and corrosive gases including hydrogen chloride (see ICSC 0163). Reacts with oxidants. Attacks some plastics and rubber. 

Occupational exposure limits
TLV: 10mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK (inhalable fraction): 15 mg/m³; Peak limitation category: II(8); Pregnancy risk group: D; (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
 

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 89°C
Density: 1.4 g/cm³
Solubility in water: none
Vapour pressure: negligible
Octanol/water partition coefficient as log Pow: 4.68/5.08  
The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Ingestion in large amounts may cause effects on the liver, kidneys and central nervous system.
Temperature of decomposition unknown in literature.
Depending on the degree of exposure, periodic medical examination is suggested.
If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Maralate, Marlate, Metox, Prentox, Methoxicide are trade names.
See also ICSC0034 for DDT.
Card has been partly updated in April 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Methoxychlor (FAO Meeting Report PL/1965/10/1)
       Methoxychlor (Pesticide residues in food: 1977 evaluations)
       Methoxychlor (IARC Summary & Evaluation, Volume 5, 1974)
       Methoxychlor (IARC Summary & Evaluation, Volume 20, 1979)