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ISONIAZID
ICSC: 1258
Peer-Review Status: 15.03.1995 Validated
Isonicotinic hydrazide
4-Pyridinecarboxylic acid, hydrazide 
CAS #: 54-85-3 RTECS #: NS1751850
EINECS #: 200-214-6
    Formula: C6H7N3O
Molecular mass: 137.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation   Use local exhaust or breathing protection.  Fresh air, rest. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes   Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Confusion. Convulsions. Nausea. Weakness. Incoordination. Hallucinations.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles.   
EC Classification
 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Cool. Well closed. 

IMPORTANT DATA
Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the nervous system and kidneys. This may result in disorientation, lethargy, coma and metabolic acidosis. Exposure at high levels could cause death. Exposure could cause unconsciousness. 

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 170-173°C
Solubility in water, g/100ml at 20°C: 12.5  
 

NOTES
Many trade names are known for this compound. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Isoniazid (PIM 288)