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HEXAMETHYLENETETRAMINE
ICSC: 1228
Peer-Review Status: 03.08.2002 Validated
1,3,5,7-Tetraazaadamantane
Methenamine
Hexamine
1,3,5,7-Tetraazatricyclo(3.3.1.1(3,7))decane 
CAS #: 100-97-0 RTECS #: MN4725000
UN #: 1328
EC #: 612-101-00-2
EINECS #: 202-905-8
 		    Formula: C6H12N4
Molecular mass: 140.2

TYPES OF
HAZARD /
EXPOSURE 		ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.   
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation Cough.  Use local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Nausea. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
 		PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.   
EC Classification
Symbol: F, Xn; R: 11-42/43; S: (2)-16-22-24-37 
UN Classification
UN Hazard Class: 4.1; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-41S1328.  Separated from strong acids and strong oxidants. Dry. 

IMPORTANT DATA
Physical State; Appearance
HYGROSCOPIC COLOURLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on heating and on burning. This produces toxic and corrosive gases including formaldehyde, ammonia, hydrogen cyanide and nitrogen oxides. The solution in water is a weak base. Reacts with strong oxidants and strong acids. Attacks aluminium and zinc. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: Sensitization of skin (SH); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of short-term exposure
The substance is mildly irritating to the eyes and skin. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Sublimation point: ~260°C
Density: 1.33 g/cm³
Solubility in water: good
Relative vapour density (air = 1): 4.9
Flash point: 250°C c.c.
Auto-ignition temperature: 390°C
Octanol/water partition coefficient as log Pow: -2.84   		 

NOTES
The substance may release formaldehyde.
See ICSC 0695 Formaldehyde.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Card has been partly updated in April 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety 		WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information. 
    See Also:
       Toxicological Abbreviations
       Hexamethylenetetramine (FAO Nutrition Meetings Report Series 38a)
       Hexamethylenetetramine (WHO Food Additives Series 1)
       Hexamethylenetetramine (WHO Food Additives Series 5)
       HEXAMETHYLENETETRAMINE (JECFA Evaluation)