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BRUCINE, ANHYDROUS
ICSC: 1017
Peer-Review Status: 03.06.2002 Validated
10,11-Dimethoxystrychnine
2,3-Dimethoxystrychnidin-10-one
2,3-Dimethylstrychnine
Dimethoxystrychnine 
CAS #: 357-57-3 RTECS #: EH8925000
UN #: 1570
EC #: 614-006-00-1
EINECS #: 206-614-7
    Formula: C23H26N2O4
Molecular mass: 394.47

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation See Ingestion.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Headache. Nausea. Vomiting. Muscle twitching. Restlessness. Convulsions. Laboured breathing.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . Avoid unnecessary stimulation of the victim. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+; R: 26/28-52/53; S: (1/2)-13-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-I.  Separated from strong oxidants and food and feedstuffs. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with strong oxidants. This generates fire and explosion hazard. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
May cause mechanical irritation. The substance may cause effects on the nervous system and eyes. This may result in convulsions and respiratory paralysis. Exposure could cause death. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 470°C
Melting point: 178°C
Solubility in water: poor
Octanol/water partition coefficient as log Pow: 0.98  
The substance is harmful to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds. 

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
The recommendations on this Card also apply to Brucine hydrate (CAS 5892-11-5). 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations