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ISOPROPYLAMINE
ICSC: 0908
Peer-Review Status: 04.10.1997 Validated
2-Propaneamine
2-Aminopropane
1-Methylethylamine 
CAS #: 75-31-0 RTECS #: NT8400000
UN #: 1221
EC #: 612-007-00-1
EINECS #: 200-860-9
    Formula: C3H9N / (CH3)2CHNH2
Molecular mass: 59.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Extremely flammable.  NO open flames, NO sparks and NO smoking.  Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Pain. Redness. Blisters. Skin burns.  Protective gloves. Protective clothing.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . 
Eyes Pain. Redness. Severe deep burns. Loss of vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Burning sensation. Abdominal cramps. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Wear protective gloves when inducing vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: F+, Xi; R: 12-36/37/38; S: (2)-16-26-29 
UN Classification
UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-656.
NFPA Code: H3; F4; R0. 
Fireproof. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. 

IMPORTANT DATA
Physical State; Appearance
HYGROSCOPIC COLOURLESS LIQUID WITH AMMONIA ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Decomposes on heating. This produces toxic fumes of nitrogen oxides and hydrogen cyanide. Reacts with strong oxidants, acids, acid anhydrides and acid chlorides. Reacts violently with nitroparaffins, halogenated hydrocarbons, oxidants and many other substances. Attacks copper and its compounds, lead, zinc and tin. 

Occupational exposure limits
TLV: 5 ppm, 12 mg/m³ as TWA; 10 ppm, 24 mg/m³ as STEL; (ACGIH 1995).
MAK: 5 ppm, 12 mg/m³;. 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure could cause death. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 33-34°C
Melting point: -95.2°C
Relative density (water = 1): 0.7
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 63.7
Relative vapour density (air = 1): 2.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.7
Auto-ignition temperature: 402°C
Explosive limits, vol% in air: 2.3-10
Octanol/water partition coefficient as log Pow: 0.3  
The substance is harmful to aquatic organisms. 

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       ISOPROPYLAMINE (JECFA Evaluation)